5VIB

Crystal structure of Protein Kinase A in complex with the PKI peptide and Aminobenzothiazole based inhibitors

5VIB の概要

• エントリーDOI: 10.2210/pdb5vib/pdb
• 関連するPDBエントリー: 5VHB 5VI9
• 分子名称: cAMP-dependent protein kinase catalytic subunit alpha, PKI peptide, 3-({[6-(pyridin-4-yl)-1,3-benzothiazol-2-yl][2-(pyrrolidin-1-yl)ethyl]amino}methyl)phenol, ... (4 entities in total)
• 機能のキーワード: kinase, transferase
• 由来する生物種: Bos taurus (Bovine); 詳細
• 細胞内の位置: Cytoplasm : P00517
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 43161.38

構造登録者

Judge, R.A. (登録日: 2017-04-14, 公開日: 2018-01-31, 最終更新日: 2018-04-04)

• 主引用文献: Judge, R.A.,Vasudevan, A.,Scott, V.E.,Simler, G.H.,Pratt, S.D.,Namovic, M.T.,Putman, C.B.,Aguirre, A.,Stoll, V.S.,Mamo, M.,Swann, S.I.,Cassar, S.C.,Faltynek, C.R.,Kage, K.L.,Boyce-Rustay, J.M.,Hobson, A.D.; Design of Aminobenzothiazole Inhibitors of Rho Kinases 1 and 2 by Using Protein Kinase A as a Structure Surrogate.; Chembiochem, 19:613-621, 2018; PubMed: 29314498; DOI: 10.1002/cbic.201700547

実験手法

X-RAY DIFFRACTION (2.37 Å)