5VH5

Crystal Structure of Fc fragment of anti-TNFa antibody infliximab

Summary for 5VH5

• Entry DOI: 10.2210/pdb5vh5/pdb
• Related: 5VH3 5VH4
• Descriptor: Infliximab Fc, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ZINC ION, ... (5 entities in total)
• Functional Keywords: antibody, fc, biosimilar, infliximab, tnfa, anti-tnfa, immune system
• Biological source: Mus musculus, Homo sapiens
• Total number of polymer chains: 1
• Total formula weight: 30038.82

Authors

Mayclin, S.J.,Edwards, T.E.,Lerch, T.F.,Conlan, H.,Sharpe, P. (deposition date: 2017-04-12, release date: 2017-05-03, Last modification date: 2023-10-04)

• Primary citation: Lerch, T.F.,Sharpe, P.,Mayclin, S.J.,Edwards, T.E.,Lee, E.,Conlon, H.D.,Polleck, S.,Rouse, J.C.,Luo, Y.,Zou, Q.; Infliximab crystal structures reveal insights into self-association.; MAbs, 9:874-883, 2017; PubMed: 28421849; DOI: 10.1080/19420862.2017.1320463

Experimental method

X-RAY DIFFRACTION (1.75 Å)