5VGO
Bruton's tyrosine kinase (BTK) with compound G-744
Summary for 5VGO
Entry DOI | 10.2210/pdb5vgo/pdb |
Related | 5VFI |
Descriptor | Tyrosine-protein kinase BTK, SULFATE ION, GLYCEROL, ... (6 entities in total) |
Functional Keywords | protein kinase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: Q06187 |
Total number of polymer chains | 1 |
Total formula weight | 32932.84 |
Authors | Yu, C.,Eigenbrot, C. (deposition date: 2017-04-11, release date: 2017-07-05, Last modification date: 2023-10-04) |
Primary citation | Wang, X.,Barbosa, J.,Blomgren, P.,Bremer, M.C.,Chen, J.,Crawford, J.J.,Deng, W.,Dong, L.,Eigenbrot, C.,Gallion, S.,Hau, J.,Hu, H.,Johnson, A.R.,Katewa, A.,Kropf, J.E.,Lee, S.H.,Liu, L.,Lubach, J.W.,Macaluso, J.,Maciejewski, P.,Mitchell, S.A.,Ortwine, D.F.,DiPaolo, J.,Reif, K.,Scheerens, H.,Schmitt, A.,Wong, H.,Xiong, J.M.,Xu, J.,Zhao, Z.,Zhou, F.,Currie, K.S.,Young, W.B. Discovery of Potent and Selective Tricyclic Inhibitors of Bruton's Tyrosine Kinase with Improved Druglike Properties. ACS Med Chem Lett, 8:608-613, 2017 Cited by PubMed: 28626519DOI: 10.1021/acsmedchemlett.7b00103 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.621 Å) |
Structure validation
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