5VGI

Crystal Structure of KDM4 with the Small Molecule Inhibitor QC6352

Summary for 5VGI

• Entry DOI: 10.2210/pdb5vgi/pdb
• Related: 5VGK
• Descriptor: Lysine-specific demethylase 4A, NICKEL (II) ION, ZINC ION, ... (5 entities in total)
• Functional Keywords: kdm4, protein-inhibitor complex, demethylase, epigenetics, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus : O75164
• Total number of polymer chains: 4
• Total formula weight: 174598.13

Authors

Hosfield, D.J. (deposition date: 2017-04-11, release date: 2017-09-27, Last modification date: 2024-03-13)

• Primary citation: Chen, Y.K.,Bonaldi, T.,Cuomo, A.,Del Rosario, J.R.,Hosfield, D.J.,Kanouni, T.,Kao, S.C.,Lai, C.,Lobo, N.A.,Matuszkiewicz, J.,McGeehan, A.,O'Connell, S.M.,Shi, L.,Stafford, J.A.,Stansfield, R.K.,Veal, J.M.,Weiss, M.S.,Yuen, N.Y.,Wallace, M.B.; Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models.; ACS Med Chem Lett, 8:869-874, 2017; PubMed: 28835804; DOI: 10.1021/acsmedchemlett.7b00220

Experimental method

X-RAY DIFFRACTION (2.07 Å)