5VFD

Diazabicyclooctenone ETX2514 bound to Class D beta lactamase OXA-24 from A. baumannii

5VFD の概要

• エントリーDOI: 10.2210/pdb5vfd/pdb
• 分子名称: Beta-lactamase, SULFATE ION, (2S,5R)-1-formyl-4-methyl-5-[(sulfooxy)amino]-1,2,5,6-tetrahydropyridine-2-carboxamide, ... (5 entities in total)
• 機能のキーワード: etx2514, beta-lactamase, pbp gram negative, astrazeneca, entasis, a. baumannii, covalent inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Acinetobacter baumannii
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 28623.50

構造登録者

Olivier, N.B.,Lahiri, S. (登録日: 2017-04-07, 公開日: 2017-06-07, 最終更新日: 2023-11-15)

• 主引用文献: Durand-Reville, T.F.,Guler, S.,Comita-Prevoir, J.,Chen, B.,Bifulco, N.,Huynh, H.,Lahiri, S.,Shapiro, A.B.,McLeod, S.M.,Carter, N.M.,Moussa, S.H.,Velez-Vega, C.,Olivier, N.B.,McLaughlin, R.,Gao, N.,Thresher, J.,Palmer, T.,Andrews, B.,Giacobbe, R.A.,Newman, J.V.,Ehmann, D.E.,de Jonge, B.,O'Donnell, J.,Mueller, J.P.,Tommasi, R.A.,Miller, A.A.; ETX2514 is a broad-spectrum beta-lactamase inhibitor for the treatment of drug-resistant Gram-negative bacteria including Acinetobacter baumannii.; Nat Microbiol, 2:17104-17104, 2017; PubMed: 28665414; DOI: 10.1038/nmicrobiol.2017.104

実験手法

X-RAY DIFFRACTION (1.93 Å)