5VEB

Crystal structure of a Fab binding to extracellular domain 5 of Cadherin-6

Summary for 5VEB

• Entry DOI: 10.2210/pdb5veb/pdb
• Descriptor: anti-CDH6 Fab heavy chain, anti-CDH6 Fab light chain, Cadherin-6, ... (6 entities in total)
• Functional Keywords: antibody, cell adhesion, antibody-drug conjugate, cancer, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 123009.37

Authors

Zhu, X.,Bialucha, C.U.,London, A.,Clark, K.,Hu, T. (deposition date: 2017-04-04, release date: 2017-06-07, Last modification date: 2024-04-24)

• Primary citation: Bialucha, C.U.,Collins, S.D.,Li, X.,Saxena, P.,Zhang, X.,Durr, C.,Lafont, B.,Prieur, P.,Shim, Y.,Mosher, R.,Lee, D.,Ostrom, L.,Hu, T.,Bilic, S.,Rajlic, I.L.,Capka, V.,Jiang, W.,Wagner, J.P.,Elliott, G.,Veloso, A.,Piel, J.C.,Flaherty, M.M.,Mansfield, K.G.,Meseck, E.K.,Rubic-Schneider, T.,London, A.S.,Tschantz, W.R.,Kurz, M.,Nguyen, D.,Bourret, A.,Meyer, M.J.,Faris, J.E.,Janatpour, M.J.,Chan, V.W.,Yoder, N.C.,Catcott, K.C.,McShea, M.A.,Sun, X.,Gao, H.,Williams, J.,Hofmann, F.,Engelman, J.A.,Ettenberg, S.A.,Sellers, W.R.,Lees, E.; Discovery and Optimization of HKT288, a Cadherin-6-Targeting ADC for the Treatment of Ovarian and Renal Cancers.; Cancer Discov, 7:1030-1045, 2017; PubMed: 28526733; DOI: 10.1158/2159-8290.CD-16-1414

Experimental method

X-RAY DIFFRACTION (2.34 Å)