5VCX

CRYSTAL STRUCTURE OF HUMAN MYT1 KINASE DOMAIN (UNTREATED) IN COMPLEX WITH SARACATINIB

5VCX の概要

• エントリーDOI: 10.2210/pdb5vcx/pdb
• 関連するPDBエントリー: 5VCV 5VCW 5VCY 5VCZ 5VD0 5VD1 5VD3
• 分子名称: Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase, N-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-7-[2-(4-METHYLPIPERAZIN-1-YL)ETHOXY]-5-(TETRAHYDRO-2H-PYRAN-4-YLOXY)QUINAZOLIN-4-AMINE, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: kinase domain, cell cycle, tyrosine- and threonine-specific kinase, membrane-associated protein kinase, transferase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35102.23

構造登録者

Zhu, J.-Y.,Schonbrunn, E. (登録日: 2017-04-01, 公開日: 2017-08-23, 最終更新日: 2023-10-04)

• 主引用文献: Zhu, J.Y.,Cuellar, R.A.,Berndt, N.,Lee, H.E.,Olesen, S.H.,Martin, M.P.,Jensen, J.T.,Georg, G.I.,Schonbrunn, E.; Structural Basis of Wee Kinases Functionality and Inactivation by Diverse Small Molecule Inhibitors.; J. Med. Chem., 60:7863-7875, 2017; PubMed: 28792760; DOI: 10.1021/acs.jmedchem.7b00996

実験手法

X-RAY DIFFRACTION (2.7 Å)