5VBU

Crystal Structure of Human Cytochrome P450 21A2 Hydroxyprogesterone Complex

Summary for 5VBU

Entry DOI	10.2210/pdb5vbu/pdb
Descriptor	Cytochrome P450 21-hydroxylase, PROTOPORPHYRIN IX CONTAINING FE, (9beta)-17-hydroxypregn-4-ene-3,20-dione, ... (4 entities in total)
Functional Keywords	steroid hydroxylation, monooxygenases, adrenal steroidogenesis, congenital adrenal hyperplasia, addison's disease, kinetic isotope effects, oxidoreductase, hydroxyprogesterone
Biological source	Homo sapiens (Human)
Total number of polymer chains	3
Total formula weight	163971.72
Authors	Pallan, P.S.,Egli, M. (deposition date: 2017-03-30, release date: 2017-05-31, Last modification date: 2022-03-23)
Primary citation	Wang, C.,Pallan, P.S.,Zhang, W.,Lei, L.,Yoshimoto, F.K.,Waterman, M.R.,Egli, M.,Guengerich, F.P. Functional analysis of human cytochrome P450 21A2 variants involved in congenital adrenal hyperplasia. J. Biol. Chem., 292:10767-10778, 2017 Cited by PubMed: 28539365 DOI: 10.1074/jbc.M117.792465 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.31 Å)

Structure validation