5VBU

Crystal Structure of Human Cytochrome P450 21A2 Hydroxyprogesterone Complex

5VBU の概要

• エントリーDOI: 10.2210/pdb5vbu/pdb
• 分子名称: Cytochrome P450 21-hydroxylase, PROTOPORPHYRIN IX CONTAINING FE, (9beta)-17-hydroxypregn-4-ene-3,20-dione, ... (4 entities in total)
• 機能のキーワード: steroid hydroxylation, monooxygenases, adrenal steroidogenesis, congenital adrenal hyperplasia, addison's disease, kinetic isotope effects, oxidoreductase, hydroxyprogesterone
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 163971.72

構造登録者

Pallan, P.S.,Egli, M. (登録日: 2017-03-30, 公開日: 2017-05-31, 最終更新日: 2024-05-22)

• 主引用文献: Wang, C.,Pallan, P.S.,Zhang, W.,Lei, L.,Yoshimoto, F.K.,Waterman, M.R.,Egli, M.,Guengerich, F.P.; Functional analysis of human cytochrome P450 21A2 variants involved in congenital adrenal hyperplasia.; J. Biol. Chem., 292:10767-10778, 2017; PubMed: 28539365; DOI: 10.1074/jbc.M117.792465

実験手法

X-RAY DIFFRACTION (3.31 Å)