5VA3

Cryo-EM structure of the human ether-a-go-go related K+ channel

5VA3 の概要

• エントリーDOI: 10.2210/pdb5va3/pdb
• 関連するPDBエントリー: 5VA1 5VA2
• EMDBエントリー: 8650 8651 8652
• 分子名称: Potassium voltage-gated channel subfamily H member 2 (1 entity in total)
• 機能のキーワード: k+ channel, pas, cnbhd, voltage sensor, selectivity filter, transport protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 88885.66

構造登録者

Wang, W.W.,MacKinnon, R. (登録日: 2017-03-24, 公開日: 2017-05-03, 最終更新日: 2024-03-13)

主引用文献

Wang, W.,MacKinnon, R.
Cryo-EM Structure of the Open Human Ether-a-go-go-Related K(+) Channel hERG.
Cell, 169:422-430.e10, 2017

PubMed Abstract: The human ether-à-go-go-related potassium channel (hERG, Kv11.1) is a voltage-dependent channel known for its role in repolarizing the cardiac action potential. hERG alteration by mutation or pharmacological inhibition produces Long QT syndrome and the lethal cardiac arrhythmia torsade de pointes. We have determined the molecular structure of hERG to 3.8 Å using cryo-electron microscopy. In this structure, the voltage sensors adopt a depolarized conformation, and the pore is open. The central cavity has an atypically small central volume surrounded by four deep hydrophobic pockets, which may explain hERG's unusual sensitivity to many drugs. A subtle structural feature of the hERG selectivity filter might correlate with its fast inactivation rate, which is key to hERG's role in cardiac action potential repolarization.

PubMed: 28431243
DOI: 10.1016/j.cell.2017.03.048

実験手法

ELECTRON MICROSCOPY (4 Å)