5VA0

Glucocorticoid Receptor DNA Binding Domain in complex with AP-1 response element from VCAM-1 Promoter

Summary for 5VA0

• Entry DOI: 10.2210/pdb5va0/pdb
• Related: 5VA7
• Descriptor: Glucocorticoid receptor, DNA (5'-D(*CP*GP*GP*CP*TP*GP*AP*CP*TP*CP*AP*TP*CP*AP*AP*G)-3'), DNA (5'-D(*CP*TP*TP*GP*AP*TP*GP*AP*GP*TP*CP*AP*GP*CP*CP*G)-3'), ... (5 entities in total)
• Functional Keywords: nuclear receptor, transcription factor, dna binding, development, protein-dna complex, transcription-dna complex, transcription/dna
• Biological source: Homo sapiens (Human); More
• Cellular location: Isoform Alpha: Cytoplasm . Isoform Beta: Nucleus . Isoform Alpha-B: Nucleus : P04150
• Total number of polymer chains: 4
• Total formula weight: 26153.98

Authors

Weikum, E.R.,Ortlund, E.A. (deposition date: 2017-03-24, release date: 2017-08-09, Last modification date: 2023-10-04)

• Primary citation: Weikum, E.R.,de Vera, I.M.S.,Nwachukwu, J.C.,Hudson, W.H.,Nettles, K.W.,Kojetin, D.J.,Ortlund, E.A.; Tethering not required: the glucocorticoid receptor binds directly to activator protein-1 recognition motifs to repress inflammatory genes.; Nucleic Acids Res., 45:8596-8608, 2017; PubMed: 28591827; DOI: 10.1093/nar/gkx509

Experimental method

X-RAY DIFFRACTION (2.295 Å)