5VA0
Glucocorticoid Receptor DNA Binding Domain in complex with AP-1 response element from VCAM-1 Promoter
Summary for 5VA0
Entry DOI | 10.2210/pdb5va0/pdb |
Related | 5VA7 |
Descriptor | Glucocorticoid receptor, DNA (5'-D(*CP*GP*GP*CP*TP*GP*AP*CP*TP*CP*AP*TP*CP*AP*AP*G)-3'), DNA (5'-D(*CP*TP*TP*GP*AP*TP*GP*AP*GP*TP*CP*AP*GP*CP*CP*G)-3'), ... (5 entities in total) |
Functional Keywords | nuclear receptor, transcription factor, dna binding, development, protein-dna complex, transcription-dna complex, transcription/dna |
Biological source | Homo sapiens (Human) More |
Cellular location | Isoform Alpha: Cytoplasm . Isoform Beta: Nucleus . Isoform Alpha-B: Nucleus : P04150 |
Total number of polymer chains | 4 |
Total formula weight | 26153.98 |
Authors | Weikum, E.R.,Ortlund, E.A. (deposition date: 2017-03-24, release date: 2017-08-09, Last modification date: 2023-10-04) |
Primary citation | Weikum, E.R.,de Vera, I.M.S.,Nwachukwu, J.C.,Hudson, W.H.,Nettles, K.W.,Kojetin, D.J.,Ortlund, E.A. Tethering not required: the glucocorticoid receptor binds directly to activator protein-1 recognition motifs to repress inflammatory genes. Nucleic Acids Res., 45:8596-8608, 2017 Cited by PubMed: 28591827DOI: 10.1093/nar/gkx509 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.295 Å) |
Structure validation
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