5V8Q

Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs): Part III

5V8Q の概要

• エントリーDOI: 10.2210/pdb5v8q/pdb
• 分子名称: Androgen receptor, GLYCEROL, 4-[(2S,3S)-2-ethyl-3-hydroxy-5-oxopyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrile, ... (4 entities in total)
• 機能のキーワード: androgen receptor, selective androgen receptor modulators, sarms, signaling protein
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus : P10275
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29562.51

構造登録者

Wilson, K.P. (登録日: 2017-03-22, 公開日: 2017-05-24, 最終更新日: 2017-11-22)

• 主引用文献: Aikawa, K.,Asano, M.,Ono, K.,Habuka, N.,Yano, J.,Wilson, K.,Fujita, H.,Kandori, H.,Hara, T.,Morimoto, M.,Santou, T.,Yamaoka, M.,Nakayama, M.,Hasuoka, A.; Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs) Part III: Discovery of 4-(5-oxopyrrolidine-1-yl)benzonitrile derivative 2f as a clinical candidate.; Bioorg. Med. Chem., 25:3330-3349, 2017; PubMed: 28454849; DOI: 10.1016/j.bmc.2017.04.018

実験手法

X-RAY DIFFRACTION (1.44 Å)