5V82

PIM1 kinase in complex with Cpd17 (1-(6-(4,4-difluoropiperidin-3-yl)pyridin-2-yl)-6-(6-methylpyrazin-2-yl)-1H-pyrazolo[4,3-c]pyridine)

Summary for 5V82

• Entry DOI: 10.2210/pdb5v82/pdb
• Related: 5V80
• Descriptor: Serine/threonine-protein kinase pim-1, 1-{6-[(3R)-4,4-difluoropiperidin-3-yl]pyridin-2-yl}-6-(6-methylpyrazin-2-yl)-1H-pyrazolo[4,3-c]pyridine (3 entities in total)
• Functional Keywords: pim1, sbdd, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
• Total number of polymer chains: 1
• Total formula weight: 34854.56

Authors

Murray, J.M.,Wallweber, H. (deposition date: 2017-03-21, release date: 2017-05-10, Last modification date: 2024-03-06)

• Primary citation: Wang, X.,Kolesnikov, A.,Tay, S.,Chan, G.,Chao, Q.,Do, S.,Drummond, J.,Ebens, A.J.,Liu, N.,Ly, J.,Harstad, E.,Hu, H.,Moffat, J.,Munugalavadla, V.,Murray, J.,Slaga, D.,Tsui, V.,Volgraf, M.,Wallweber, H.,Chang, J.H.; Discovery of 5-Azaindazole (GNE-955) as a Potent Pan-Pim Inhibitor with Optimized Bioavailability.; J. Med. Chem., 60:4458-4473, 2017; PubMed: 28445037; DOI: 10.1021/acs.jmedchem.7b00418

Experimental method

X-RAY DIFFRACTION (1.888 Å)