5V80
PIM1 kinase in complex with Cpd1 (1-methyl-4-(3-(6-(piperazin-1-yl)pyridin-2-yl)-1H-pyrazolo[3,4-c]pyridin-5-yl)piperazin-2-one)
Summary for 5V80
Entry DOI | 10.2210/pdb5v80/pdb |
Descriptor | Serine/threonine-protein kinase pim-1, PHOSPHATE ION, 1-methyl-4-{3-[6-(piperazin-1-yl)pyridin-2-yl]-1H-pyrazolo[3,4-c]pyridin-5-yl}piperazin-2-one, ... (4 entities in total) |
Functional Keywords | pim1, sbdd, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309 |
Total number of polymer chains | 1 |
Total formula weight | 34934.57 |
Authors | Murray, J.M.,Wallweber, H. (deposition date: 2017-03-21, release date: 2018-04-18, Last modification date: 2024-03-06) |
Primary citation | Wang, X.,Kolesnikov, A.,Tay, S.,Chan, G.,Chao, Q.,Do, S.,Drummond, J.,Ebens, A.J.,Liu, N.,Ly, J.,Harstad, E.,Hu, H.,Moffat, J.,Munugalavadla, V.,Murray, J.,Slaga, D.,Tsui, V.,Volgraf, M.,Wallweber, H.,Chang, J.H. Discovery of 5-Azaindazole (GNE-955) as a Potent Pan-Pim Inhibitor with Optimized Bioavailability. J. Med. Chem., 60:4458-4473, 2017 Cited by PubMed: 28445037DOI: 10.1021/acs.jmedchem.7b00418 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.252 Å) |
Structure validation
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