5V7J

Crystal Structure at 3.7 A Resolution of Glycosylated HIV-1 Clade A BG505 SOSIP.664 Prefusion Env Trimer with Four Glycans (N197, N276, N362, and N462) removed in Complex with Neutralizing Antibodies 3H+109L and 35O22.

5V7J の概要

• エントリーDOI: 10.2210/pdb5v7j/pdb
• 分子名称: Envelope glycoprotein gp160, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (16 entities in total)
• 機能のキーワード: hiv-1, envelope, antibody, virus, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Human immunodeficiency virus 1; 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 183203.78

構造登録者

Stewart-Jones, G.B.E.,Zhou, T.,Kwong, P.D. (登録日: 2017-03-20, 公開日: 2017-06-21, 最終更新日: 2023-10-04)

• 主引用文献: Zhou, T.,Doria-Rose, N.A.,Cheng, C.,Stewart-Jones, G.B.E.,Chuang, G.Y.,Chambers, M.,Druz, A.,Geng, H.,McKee, K.,Kwon, Y.D.,O'Dell, S.,Sastry, M.,Schmidt, S.D.,Xu, K.,Chen, L.,Chen, R.E.,Louder, M.K.,Pancera, M.,Wanninger, T.G.,Zhang, B.,Zheng, A.,Farney, S.K.,Foulds, K.E.,Georgiev, I.S.,Joyce, M.G.,Lemmin, T.,Narpala, S.,Rawi, R.,Soto, C.,Todd, J.P.,Shen, C.H.,Tsybovsky, Y.,Yang, Y.,Zhao, P.,Haynes, B.F.,Stamatatos, L.,Tiemeyer, M.,Wells, L.,Scorpio, D.G.,Shapiro, L.,McDermott, A.B.,Mascola, J.R.,Kwong, P.D.; Quantification of the Impact of the HIV-1-Glycan Shield on Antibody Elicitation.; Cell Rep, 19:719-732, 2017; PubMed: 28445724; DOI: 10.1016/j.celrep.2017.04.013

実験手法

X-RAY DIFFRACTION (2.907 Å)