5V76

Structure of Haliangium ochraceum BMC-T HO-3341

5V76 の概要

• エントリーDOI: 10.2210/pdb5v76/pdb
• 関連するPDBエントリー: 5V74 5V75
• 分子名称: Microcompartments protein, GLYCEROL (3 entities in total)
• 機能のキーワード: bacterial microcompartments, structural protein
• 由来する生物種: Haliangium ochraceum (strain DSM 14365 / JCM 11303 / SMP-2)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 43835.87

構造登録者

Sutter, M.,Paasch, B.,Zarzycki, J.,Aussignargues, C.,Kerfeld, C.A. (登録日: 2017-03-17, 公開日: 2017-06-21, 最終更新日: 2023-10-04)

主引用文献

Sutter, M.,Greber, B.,Aussignargues, C.,Kerfeld, C.A.
Assembly principles and structure of a 6.5-MDa bacterial microcompartment shell.
Science, 356:1293-1297, 2017

PubMed Abstract: Many bacteria contain primitive organelles composed entirely of protein. These bacterial microcompartments share a common architecture of an enzymatic core encapsulated in a selectively permeable protein shell; prominent examples include the carboxysome for CO fixation and catabolic microcompartments found in many pathogenic microbes. The shell sequesters enzymatic reactions from the cytosol, analogous to the lipid-based membrane of eukaryotic organelles. Despite available structural information for single building blocks, the principles of shell assembly have remained elusive. We present the crystal structure of an intact shell from , revealing the basic principles of bacterial microcompartment shell construction. Given the conservation among shell proteins of all bacterial microcompartments, these principles apply to functionally diverse organelles and can inform the design and engineering of shells with new functionalities.

PubMed: 28642439
DOI: 10.1126/science.aan3289

実験手法

X-RAY DIFFRACTION (1.55 Å)