5V6U
Crystal structure of human caspase-7 soaked with allosteric inhibitor 2-[(2-acetylphenyl)sulfanyl]benzoic acid
Summary for 5V6U
Entry DOI | 10.2210/pdb5v6u/pdb |
Related | 5V6Z |
Descriptor | Caspase-7, 2-[(2-acetylphenyl)sulfanyl]benzoic acid (3 entities in total) |
Functional Keywords | hydrolase, protease, inhibitor, allosteric, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: P55210 |
Total number of polymer chains | 2 |
Total formula weight | 68919.98 |
Authors | Vance, N.R.,Gakhar, L.,Spies, M.A. (deposition date: 2017-03-17, release date: 2017-10-18, Last modification date: 2023-10-04) |
Primary citation | Vance, N.R.,Gakhar, L.,Spies, M.A. Allosteric Tuning of Caspase-7: A Fragment-Based Drug Discovery Approach. Angew. Chem. Int. Ed. Engl., 56:14443-14447, 2017 Cited by PubMed: 28940929DOI: 10.1002/anie.201706959 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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