5V5S
multi-drug efflux; membrane transport; RND superfamily; Drug resistance
Summary for 5V5S
Entry DOI | 10.2210/pdb5v5s/pdb |
EMDB information | 8636 |
Descriptor | Outer membrane protein TolC, Multidrug efflux pump subunit AcrA, Multidrug efflux pump subunit AcrB (3 entities in total) |
Functional Keywords | multi-drug efflux, membrane transport, rnd superfamily, drug resistance, membrane protein |
Biological source | Escherichia coli More |
Total number of polymer chains | 12 |
Total formula weight | 740586.44 |
Authors | wang, Z.,fan, G.,Hryc, C.F.,Blaza, J.N.,Serysheva, I.I.,Schmid, M.F.,Chiu, W.,Luisi, B.F.,Du, D. (deposition date: 2017-03-15, release date: 2017-04-19, Last modification date: 2019-10-23) |
Primary citation | Wang, Z.,Fan, G.,Hryc, C.F.,Blaza, J.N.,Serysheva, I.I.,Schmid, M.F.,Chiu, W.,Luisi, B.F.,Du, D. An allosteric transport mechanism for the AcrAB-TolC Multidrug Efflux Pump. Elife, 6:-, 2017 Cited by PubMed: 28355133DOI: 10.7554/eLife.24905 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (6.5 Å) |
Structure validation
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