5V5E

Room temperature (280K) crystal structure of Kaposi's sarcoma-associated herpesvirus protease in complex with allosteric inhibitor (compound 733)

5V5E の概要

• エントリーDOI: 10.2210/pdb5v5e/pdb
• 関連するPDBエントリー: 5V5D
• 分子名称: ORF 17, 4-{[6-(cyclohexylmethyl)pyridine-2-carbonyl]amino}-3-{[3-(trifluoromethoxy)phenyl]amino}benzoic acid (3 entities in total)
• 機能のキーワード: protease, allosteric inhibitor, herpesvirus, viral protein - inhibitor complex, viral protein / inhibitor
• 由来する生物種: Human herpesvirus 8 (HHV-8)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 43926.75

構造登録者

Thompson, M.C.,Acker, T.M.,Fraser, J.S.,Craik, C.S. (登録日: 2017-03-14, 公開日: 2017-04-12, 最終更新日: 2023-10-04)

• 主引用文献: Acker, T.M.,Gable, J.E.,Bohn, M.F.,Jaishankar, P.,Thompson, M.C.,Fraser, J.S.,Renslo, A.R.,Craik, C.S.; Allosteric Inhibitors, Crystallography, and Comparative Analysis Reveal Network of Coordinated Movement across Human Herpesvirus Proteases.; J. Am. Chem. Soc., 139:11650-11653, 2017; PubMed: 28759216; DOI: 10.1021/jacs.7b04030

実験手法

X-RAY DIFFRACTION (2.299 Å)