5V56
2.9A XFEL structure of the multi-domain human smoothened receptor (with E194M mutation) in complex with TC114
Summary for 5V56
Entry DOI | 10.2210/pdb5v56/pdb |
Related | 5V57 |
Descriptor | Smoothened homolog,Flavodoxin,Smoothened homolog, N-methyl-N-[1-[4-(2-methylpyrazol-3-yl)phthalazin-1-yl]piperidin-4-yl]-4-nitro-2-(trifluoromethyl)benzamide, FLAVIN MONONUCLEOTIDE, ... (4 entities in total) |
Functional Keywords | human smoothened receptor complex, gpcr hedgehog signaling, gpcr, class f, 7tm domain, hinge domain, extracellular cystein-rich domain, flavodoxin, membrane protein, lcp, xfel, tc114 |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 147366.09 |
Authors | Zhang, X.,Zhao, F.,Wu, Y.,Yang, J.,Han, G.W.,Zhao, S.,Ishchenko, A.,Ye, L.,Lin, X.,Ding, K.,Dharmarajan, V.,Griffin, P.R.,Gati, C.,Nelson, G.,Hunter, M.S.,Hanson, M.A.,Cherezov, V.,Stevens, R.C.,Tan, W.,Tao, H.,Xu, F. (deposition date: 2017-03-13, release date: 2017-05-24, Last modification date: 2023-11-08) |
Primary citation | Zhang, X.,Zhao, F.,Wu, Y.,Yang, J.,Han, G.W.,Zhao, S.,Ishchenko, A.,Ye, L.,Lin, X.,Ding, K.,Dharmarajan, V.,Griffin, P.R.,Gati, C.,Nelson, G.,Hunter, M.S.,Hanson, M.A.,Cherezov, V.,Stevens, R.C.,Tan, W.,Tao, H.,Xu, F. Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand. Nat Commun, 8:15383-15383, 2017 Cited by PubMed: 28513578DOI: 10.1038/ncomms15383 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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