5V4Y

X-ray crystal structure of wild type HIV-1 protease in complex with GRL-09510

5V4Y の概要

• エントリーDOI: 10.2210/pdb5v4y/pdb
• 分子名称: Protease, (3S,3aR,5R,7aS,8S)-hexahydro-4H-3,5-methanofuro[2,3-b]pyran-8-yl [(2S,3R)-3-hydroxy-4-{[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino}-1-phenylbutan-2-yl]carbamate (3 entities in total)
• 機能のキーワード: grl-09510, hiv-1 protease, protease-inhibitor, pyran, furan, nonpeptidic, hydrolase-hydrolase inhibitor complex, crown-thf, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus 1
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 11314.31

構造登録者

Yedidi, R.S.,Delino, N.S.,Das, D.,Kaufman, J.D.,Wingfield, P.T.,Ghosh, A.K.,Mitsuya, H. (登録日: 2017-03-11, 公開日: 2017-09-13, 最終更新日: 2023-10-04)

• 主引用文献: Amano, M.,Miguel Salcedo-Gomez, P.,Yedidi, R.S.,Delino, N.S.,Nakata, H.,Venkateswara Rao, K.,Ghosh, A.K.,Mitsuya, H.; GRL-09510, a Unique P2-Crown-Tetrahydrofuranylurethane -Containing HIV-1 Protease Inhibitor, Maintains Its Favorable Antiviral Activity against Highly-Drug-Resistant HIV-1 Variants in vitro.; Sci Rep, 7:12235-12235, 2017; PubMed: 28947797; DOI: 10.1038/s41598-017-12052-9

実験手法

X-RAY DIFFRACTION (1.9 Å)