5V4R

Crystal structure of LARP1-unique domain DM15 bound to m7GTP

Summary for 5V4R

Entry DOI	10.2210/pdb5v4r/pdb
Descriptor	La-related protein 1, 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE (3 entities in total)
Functional Keywords	cap-binding, rna-binding, dm15, rna binding protein
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm : Q6PKG0
Total number of polymer chains	2
Total formula weight	39771.78
Authors	Berman, A.J.,Lahr, R.M. (deposition date: 2017-03-10, release date: 2017-04-19, Last modification date: 2023-10-04)
Primary citation	Lahr, R.M.,Fonseca, B.D.,Ciotti, G.E.,Al-Ashtal, H.A.,Jia, J.J.,Niklaus, M.R.,Blagden, S.P.,Alain, T.,Berman, A.J. La-related protein 1 (LARP1) binds the mRNA cap, blocking eIF4F assembly on TOP mRNAs. Elife, 6:-, 2017 Cited by PubMed: 28379136 DOI: 10.7554/eLife.24146 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.77 Å)

Structure validation