5V4I

Osmium(II)(cymene)(chlorido)2-lysozyme adduct with one binding site

5V4I の概要

• エントリーDOI: 10.2210/pdb5v4i/pdb
• 関連するPDBエントリー: 5V4G 5V4H
• 分子名称: Lysozyme C, SODIUM ION, dichloro[(1,2,3,4,5,6-eta)-3-methyl-6-(propan-2-yl)benzene-1,2,4,5-tetrayl]osmium, ... (4 entities in total)
• 機能のキーワード: metal-based, anticancer, osmium, lysozyme, hydrolase
• 由来する生物種: Gallus gallus (Chicken)
• 細胞内の位置: Secreted: P00698
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 14745.47

構造登録者

Sullivan, M.P.,Hartinger, C.G.,Goldstone, D.C. (登録日: 2017-03-09, 公開日: 2017-04-05, 最終更新日: 2024-11-13)

主引用文献

Sullivan, M.P.,Groessl, M.,Meier, S.M.,Kingston, R.L.,Goldstone, D.C.,Hartinger, C.G.
The metalation of hen egg white lysozyme impacts protein stability as shown by ion mobility mass spectrometry, differential scanning calorimetry, and X-ray crystallography.
Chem. Commun. (Camb.), 53:4246-4249, 2017

PubMed Abstract: Metalation of hen egg white lysozyme (HEWL) with organometallics was studied with physicochemical methods in solid state, solution and the gas phase. While metalation did not affect the crystal structure of HEWL significantly, protein destabilisation was detected in gas phase and solution.

PubMed: 28361137
DOI: 10.1039/c6cc10150j

実験手法

X-RAY DIFFRACTION (1.5 Å)