5V4E
Engineered human IgG Fc domain glyco801 (Fc801)
Summary for 5V4E
Entry DOI | 10.2210/pdb5v4e/pdb |
Descriptor | Ig gamma-1 chain C region, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose, ... (10 entities in total) |
Functional Keywords | antibody engineering, fc fragment, igg, immune system |
Biological source | Homo sapiens (Human) |
Cellular location | Secreted : P01857 |
Total number of polymer chains | 8 |
Total formula weight | 211247.08 |
Authors | Yan, W.,Marshall, N.,Zhang, Y.J. (deposition date: 2017-03-09, release date: 2017-06-21, Last modification date: 2020-07-29) |
Primary citation | Lee, C.H.,Romain, G.,Yan, W.,Watanabe, M.,Charab, W.,Todorova, B.,Lee, J.,Triplett, K.,Donkor, M.,Lungu, O.I.,Lux, A.,Marshall, N.,Lindorfer, M.A.,Goff, O.R.,Balbino, B.,Kang, T.H.,Tanno, H.,Delidakis, G.,Alford, C.,Taylor, R.P.,Nimmerjahn, F.,Varadarajan, N.,Bruhns, P.,Zhang, Y.J.,Georgiou, G. IgG Fc domains that bind C1q but not effector Fc gamma receptors delineate the importance of complement-mediated effector functions. Nat. Immunol., 18:889-898, 2017 Cited by PubMed: 28604720DOI: 10.1038/ni.3770 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.216 Å) |
Structure validation
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