5V37

Crystal structure of SMYD3 with SAM and EPZ028862

Summary for 5V37

• Entry DOI: 10.2210/pdb5v37/pdb
• Related: 5V3H
• Descriptor: Histone-lysine N-methyltransferase SMYD3, ZINC ION, S-ADENOSYLMETHIONINE, ... (8 entities in total)
• Functional Keywords: protein-inhibitor complex, protein lysine methyltransferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 50615.90

Authors

Boriack-Sjodin, P.A. (deposition date: 2017-03-06, release date: 2018-03-07, Last modification date: 2024-03-06)

• Primary citation: Thomenius, M.J.,Totman, J.,Harvey, D.,Mitchell, L.H.,Riera, T.V.,Cosmopoulos, K.,Grassian, A.R.,Klaus, C.,Foley, M.,Admirand, E.A.,Jahic, H.,Majer, C.,Wigle, T.,Jacques, S.L.,Gureasko, J.,Brach, D.,Lingaraj, T.,West, K.,Smith, S.,Rioux, N.,Waters, N.J.,Tang, C.,Raimondi, A.,Munchhof, M.,Mills, J.E.,Ribich, S.,Porter Scott, M.,Kuntz, K.W.,Janzen, W.P.,Moyer, M.,Smith, J.J.,Chesworth, R.,Copeland, R.A.,Boriack-Sjodin, P.A.; Small molecule inhibitors and CRISPR/Cas9 mutagenesis demonstrate that SMYD2 and SMYD3 activity are dispensable for autonomous cancer cell proliferation.; Plos One, 13:e0197372-e0197372, 2018; PubMed: 29856759; DOI: 10.1371/journal.pone.0197372

Experimental method

X-RAY DIFFRACTION (1.42 Å)