5UWG

The crystal structure of Fz4-CRD in complex with palmitoleic acid

Summary for 5UWG

Entry DOI	10.2210/pdb5uwg/pdb
Related	5CL1 5CM4
Descriptor	Frizzled-4, PALMITOLEIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
Functional Keywords	wnt, frizzled, signalosome, cysteine-rich domain, wnt5a, wnt8, frizzled-4, signaling protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	29212.70
Authors	Ke, J.,DeBruine, Z.J.,Gu, X.,Brunzelle, J.S.,Xu, H.E.,Melcher, K. (deposition date: 2017-02-21, release date: 2017-06-14, Last modification date: 2023-10-04)
Primary citation	DeBruine, Z.J.,Ke, J.,Harikumar, K.G.,Gu, X.,Borowsky, P.,Williams, B.O.,Xu, W.,Miller, L.J.,Xu, H.E.,Melcher, K. Wnt5a promotes Frizzled-4 signalosome assembly by stabilizing cysteine-rich domain dimerization. Genes Dev., 31:916-926, 2017 Cited by PubMed: 28546512 DOI: 10.1101/gad.298331.117 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.56 Å)

Structure validation