5UWG
The crystal structure of Fz4-CRD in complex with palmitoleic acid
Summary for 5UWG
Entry DOI | 10.2210/pdb5uwg/pdb |
Related | 5CL1 5CM4 |
Descriptor | Frizzled-4, PALMITOLEIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total) |
Functional Keywords | wnt, frizzled, signalosome, cysteine-rich domain, wnt5a, wnt8, frizzled-4, signaling protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 29212.70 |
Authors | Ke, J.,DeBruine, Z.J.,Gu, X.,Brunzelle, J.S.,Xu, H.E.,Melcher, K. (deposition date: 2017-02-21, release date: 2017-06-14, Last modification date: 2024-10-09) |
Primary citation | DeBruine, Z.J.,Ke, J.,Harikumar, K.G.,Gu, X.,Borowsky, P.,Williams, B.O.,Xu, W.,Miller, L.J.,Xu, H.E.,Melcher, K. Wnt5a promotes Frizzled-4 signalosome assembly by stabilizing cysteine-rich domain dimerization. Genes Dev., 31:916-926, 2017 Cited by PubMed: 28546512DOI: 10.1101/gad.298331.117 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.56 Å) |
Structure validation
Download full validation report