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5UVC

Design, Synthesis, and Evaluation of the First Selective and Potent G-protein-Coupled Receptor Kinase 2 (GRK2) Inhibitor for the Potential Treatment of Heart Failure

Summary for 5UVC
Entry DOI10.2210/pdb5uvc/pdb
Related5UUU
DescriptorBeta-adrenergic receptor kinase 1, N-benzyl-3-({[5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl]methyl}amino)benzamide, SULFATE ION, ... (4 entities in total)
Functional Keywordskinase, inhibitor, heart failure, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm : P25098
Total number of polymer chains1
Total formula weight63812.66
Authors
Hoffman, I.D.,Lawson, J.D. (deposition date: 2017-02-20, release date: 2017-07-26, Last modification date: 2024-03-06)
Primary citationOkawa, T.,Aramaki, Y.,Yamamoto, M.,Kobayashi, T.,Fukumoto, S.,Toyoda, Y.,Henta, T.,Hata, A.,Ikeda, S.,Kaneko, M.,Hoffman, I.D.,Sang, B.C.,Zou, H.,Kawamoto, T.
Design, Synthesis, and Evaluation of the Highly Selective and Potent G-Protein-Coupled Receptor Kinase 2 (GRK2) Inhibitor for the Potential Treatment of Heart Failure.
J. Med. Chem., 60:6942-6990, 2017
Cited by
PubMed: 28699740
DOI: 10.1021/acs.jmedchem.7b00443
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.65 Å)
Structure validation

221051

건을2024-06-12부터공개중

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