5UUU
Design, Synthesis, and Evaluation of the First Selective and Potent G-protein-Coupled Receptor Kinase 2 (GRK2) Inhibitor for the Potential Treatment of Heart Failure
5UUU の概要
エントリーDOI | 10.2210/pdb5uuu/pdb |
関連するPDBエントリー | 5UVC |
分子名称 | Beta-adrenergic receptor kinase 1, 3-({[4-methyl-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl]methyl}amino)-N-[2-(trifluoromethyl)benzyl]benzamide, SULFATE ION, ... (5 entities in total) |
機能のキーワード | kinase, inhibitor, heart failure, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
由来する生物種 | Homo sapiens (Human) |
細胞内の位置 | Cytoplasm : P25098 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 64089.92 |
構造登録者 | |
主引用文献 | Okawa, T.,Aramaki, Y.,Yamamoto, M.,Kobayashi, T.,Fukumoto, S.,Toyoda, Y.,Henta, T.,Hata, A.,Ikeda, S.,Kaneko, M.,Hoffman, I.D.,Sang, B.C.,Zou, H.,Kawamoto, T. Design, Synthesis, and Evaluation of the Highly Selective and Potent G-Protein-Coupled Receptor Kinase 2 (GRK2) Inhibitor for the Potential Treatment of Heart Failure. J. Med. Chem., 60:6942-6990, 2017 Cited by PubMed: 28699740DOI: 10.1021/acs.jmedchem.7b00443 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.7 Å) |
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