5UTQ
Crystal structure of Burkholderia cenocepacia family 3 glycoside hydrolase (NagZ) bound to PUGNAc
Summary for 5UTQ
Entry DOI | 10.2210/pdb5utq/pdb |
Related | 4G6C 4GNV 4MSS 5UTP |
Descriptor | Beta-hexosaminidase, O-(2-ACETAMIDO-2-DEOXY D-GLUCOPYRANOSYLIDENE) AMINO-N-PHENYLCARBAMATE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (4 entities in total) |
Functional Keywords | glycoside hydrolase, gh, family 3, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Burkholderia cenocepacia |
Cellular location | Cytoplasm : A0A125HFC0 |
Total number of polymer chains | 2 |
Total formula weight | 77135.42 |
Authors | Vadlamani, G.,Mark, B.L. (deposition date: 2017-02-15, release date: 2017-04-19, Last modification date: 2023-10-04) |
Primary citation | Vadlamani, G.,Stubbs, K.A.,Desire, J.,Bleriot, Y.,Vocadlo, D.J.,Mark, B.L. Conformational flexibility of the glycosidase NagZ allows it to bind structurally diverse inhibitors to suppress beta-lactam antibiotic resistance. Protein Sci., 26:1161-1170, 2017 Cited by PubMed: 28370529DOI: 10.1002/pro.3166 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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