5UT1
JAK2 JH2 in complex with BI-D1870
Summary for 5UT1
| Entry DOI | 10.2210/pdb5ut1/pdb |
| Related | 5USY 5USZ 5UT0 5UT2 5UT3 5UT4 5UT5 5UT6 |
| Descriptor | Tyrosine-protein kinase JAK2, GLYCEROL, (7S)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5H)-one, ... (4 entities in total) |
| Functional Keywords | pseudokinase domain, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 33880.75 |
| Authors | Puleo, D.E.,Schlessinger, J. (deposition date: 2017-02-14, release date: 2017-06-07, Last modification date: 2023-10-04) |
| Primary citation | Puleo, D.E.,Kucera, K.,Hammaren, H.M.,Ungureanu, D.,Newton, A.S.,Silvennoinen, O.,Jorgensen, W.L.,Schlessinger, J. Identification and Characterization of JAK2 Pseudokinase Domain Small Molecule Binders. ACS Med Chem Lett, 8:618-621, 2017 Cited by PubMed: 28626521DOI: 10.1021/acsmedchemlett.7b00153 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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