5USF

Leishmania donovani tyrosyl-tRNA synthetase in complex with nanobody and inhibitor

Summary for 5USF

Entry DOI	10.2210/pdb5usf/pdb
Descriptor	Tyrosyl-tRNA synthetase, putative, Immunoglobulin heavy chain variable region, 5'-O-[N-(L-TYROSYL)SULFAMOYL]ADENOSINE, ... (4 entities in total)
Functional Keywords	synthetase, ligase, tyrosine, inhibitor, ligase-ligase inhibitor complex, tyrosyl-adenylate analog, ligase/ligase inhibitor
Biological source	Leishmania donovani (strain BPK282A1) More
Total number of polymer chains	4
Total formula weight	180123.32
Authors	Barros-Alvarez, X.,Hol, W.G.J. (deposition date: 2017-02-13, release date: 2017-05-17, Last modification date: 2023-10-04)
Primary citation	Barros-Alvarez, X.,Kerchner, K.M.,Koh, C.Y.,Turley, S.,Pardon, E.,Steyaert, J.,Ranade, R.M.,Gillespie, J.R.,Zhang, Z.,Verlinde, C.L.M.J.,Fan, E.,Buckner, F.S.,Hol, W.G.J. Leishmania donovani tyrosyl-tRNA synthetase structure in complex with a tyrosyl adenylate analog and comparisons with human and protozoan counterparts. Biochimie, 138:124-136, 2017 Cited by PubMed: 28427904 DOI: 10.1016/j.biochi.2017.04.006 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.75 Å)

Structure validation