5USF

Leishmania donovani tyrosyl-tRNA synthetase in complex with nanobody and inhibitor

5USF の概要

• エントリーDOI: 10.2210/pdb5usf/pdb
• 分子名称: Tyrosyl-tRNA synthetase, putative, Immunoglobulin heavy chain variable region, 5'-O-[N-(L-TYROSYL)SULFAMOYL]ADENOSINE, ... (4 entities in total)
• 機能のキーワード: synthetase, ligase, tyrosine, inhibitor, ligase-ligase inhibitor complex, tyrosyl-adenylate analog, ligase/ligase inhibitor
• 由来する生物種: Leishmania donovani (strain BPK282A1); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 180123.32

構造登録者

Barros-Alvarez, X.,Hol, W.G.J. (登録日: 2017-02-13, 公開日: 2017-05-17, 最終更新日: 2023-10-04)

• 主引用文献: Barros-Alvarez, X.,Kerchner, K.M.,Koh, C.Y.,Turley, S.,Pardon, E.,Steyaert, J.,Ranade, R.M.,Gillespie, J.R.,Zhang, Z.,Verlinde, C.L.M.J.,Fan, E.,Buckner, F.S.,Hol, W.G.J.; Leishmania donovani tyrosyl-tRNA synthetase structure in complex with a tyrosyl adenylate analog and comparisons with human and protozoan counterparts.; Biochimie, 138:124-136, 2017; PubMed: 28427904; DOI: 10.1016/j.biochi.2017.04.006

実験手法

X-RAY DIFFRACTION (2.75 Å)