5US8

2.15 Angstrom Resolution Crystal Structure of Argininosuccinate Synthase from Bordetella pertussis

5US8 の概要

• エントリーDOI: 10.2210/pdb5us8/pdb
• 分子名称: Argininosuccinate synthase, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, TRIETHYLENE GLYCOL, ... (6 entities in total)
• 機能のキーワード: structural genomics, center for structural genomics of infectious diseases, csgid, argininosuccinate synthase, hydrolase, oxidoreductase
• 由来する生物種: Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
• 細胞内の位置: Cytoplasm : Q7VTJ9
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 100522.70

構造登録者

Minasov, G.,Shuvalova, L.,Dubrovska, I.,Winsor, J.,Stam, J.,Kwon, K.,Anderson, W.F.,Center for Structural Genomics of Infectious Diseases (CSGID) (登録日: 2017-02-13, 公開日: 2017-03-01, 最終更新日: 2026-02-11)

主引用文献

Inniss, N.L.,Minasov, G.,Chang, C.,Tan, K.,Kim, Y.,Maltseva, N.,Stogios, P.,Filippova, E.,Michalska, K.,Osipiuk, J.,Jaroszewki, L.,Godzik, A.,Savchenko, A.,Joachimiak, A.,Anderson, W.F.,Satchell, K.J.F.
Structural genomics of bacterial drug targets: Application of a high-throughput pipeline to solve 58 protein structures from pathogenic and related bacteria.
Microbiol Resour Announc, 14:e0020025-e0020025, 2025

PubMed Abstract: Antibiotic resistance remains a leading cause of severe infections worldwide. Small changes in protein sequence can impact antibiotic efficacy. Here, we report deposition of 58 X-ray crystal structures of bacterial proteins that are known targets for antibiotics, which expands knowledge of structural variation to support future antibiotic discovery or modifications.

PubMed: 40391899
DOI: 10.1128/mra.00200-25

実験手法

X-RAY DIFFRACTION (2.15 Å)