5URC

Design, Synthesis, Functional and Biological Evaluation of Ether and Ester Derivatives of the Antisickling Agent 5-HMF for the Treatment of Sickle Cell Disease

5URC の概要

• エントリーDOI: 10.2210/pdb5urc/pdb
• 分子名称: Hemoglobin subunit alpha, Hemoglobin subunit beta, CARBON MONOXIDE, ... (7 entities in total)
• 機能のキーワード: hemoglobin, antisickling, allosteric effector, aromatic aldehyde, oxygen transport
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 64953.35

構造登録者

Pagare, P.P.,Safo, R.S.,Gazi, A. (登録日: 2017-02-10, 公開日: 2017-03-15, 最終更新日: 2023-10-04)

• 主引用文献: Xu, G.G.,Pagare, P.P.,Ghatge, M.S.,Safo, R.P.,Gazi, A.,Chen, Q.,David, T.,Alabbas, A.B.,Musayev, F.N.,Venitz, J.,Zhang, Y.,Safo, M.K.,Abdulmalik, O.; Design, Synthesis, and Biological Evaluation of Ester and Ether Derivatives of Antisickling Agent 5-HMF for the Treatment of Sickle Cell Disease.; Mol. Pharm., 14:3499-3511, 2017; PubMed: 28858508; DOI: 10.1021/acs.molpharmaceut.7b00553

実験手法

X-RAY DIFFRACTION (1.85 Å)