5UPJ

HIV-2 PROTEASE/U99283 COMPLEX

5UPJ の概要

• エントリーDOI: 10.2210/pdb5upj/pdb
• 分子名称: HIV-2 PROTEASE, 5,6,7,8,9,10-HEXAHYDRO-4-HYDROXY-3-(1-PHENYLPROPYL)CYCLOOCTA[B]PYRAN-2-ONE (3 entities in total)
• 機能のキーワード: hydrolase, acid protease, hiv-2 protease-inhibitor complex, protein-substrate interaction, aspartyl protease
• 由来する生物種: Human immunodeficiency virus 2
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04584
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 21737.03

構造登録者

Watenpaugh, K.D.,Mulichak, A.M.,Finzel, B.C. (登録日: 1996-12-10, 公開日: 1997-04-21, 最終更新日: 2024-04-03)

• 主引用文献: Romines, K.R.,Watenpaugh, K.D.,Tomich, P.K.,Howe, W.J.,Morris, J.K.,Lovasz, K.D.,Mulichak, A.M.,Finzel, B.C.,Lynn, J.C.,Horng, M.-M.,Schwende, F.J.,Ruwart, M.J.,Zipp, G.L.,Chong, K.-T.,Dolak, L.A.,Toth, L.N.,Howard, G.M.,Rush, B.D.,Wilkinson, K.F.,Possert, P.L.,Dalga, R.J.,Hinshaw, R.R.; Use of medium-sized cycloalkyl rings to enhance secondary binding: discovery of a new class of human immunodeficiency virus (HIV) protease inhibitors.; J.Med.Chem., 38:1884-1891, 1995; PubMed: 7783120; DOI: 10.1021/jm00011a008

実験手法

X-RAY DIFFRACTION (2.3 Å)