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5UO1

Structure of human neuronal nitric oxide synthase heme domain in complex with 3-[(2-aminoquinolin-7-yl)methoxy]-5-((methylamino)methyl)benzonitrile

Summary for 5UO1
Entry DOI10.2210/pdb5uo1/pdb
Related5UNR 5UNS 5UNT 5UNU 5UNV 5UNW 5UNX 5UNY 5UNZ 5UO0 5UO2 5UO3 5UO4 5UO5 5UO6 5UO7 5UO8 5UO9 5UOA 5UOB 5UOC 5UOD
DescriptorNitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total)
Functional Keywordsnitric, oxide, synthase, inhibitor, complex, heme, enzyme, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight100078.71
Authors
Li, H.,Poulos, T.L. (deposition date: 2017-01-31, release date: 2017-05-03, Last modification date: 2023-10-04)
Primary citationCinelli, M.A.,Li, H.,Chreifi, G.,Poulos, T.L.,Silverman, R.B.
Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2-Aminoquinoline Inhibitors.
J. Med. Chem., 60:3958-3978, 2017
Cited by
PubMed: 28422508
DOI: 10.1021/acs.jmedchem.7b00259
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation

217705

數據於2024-03-27公開中

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