5UNP

Structure of CDC2-Like Kinase 2 (CLK2) in Complex with Compound T-025 [N2-methyl-N4-(pyrimidin-2-ylmethyl)-5-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine]

5UNP の概要

• エントリーDOI: 10.2210/pdb5unp/pdb
• 分子名称: Dual specificity protein kinase CLK2, N~2~-methyl-N~4~-[(pyrimidin-2-yl)methyl]-5-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine (3 entities in total)
• 機能のキーワード: protein kinase, dual specificity protein kinase, inhibitor, transferase, complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Isoform 1: Nucleus. Isoform 2: Nucleus speckle: P49760
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 87507.01

構造登録者

Klein, M.G.,Tjhen, R. (登録日: 2017-01-31, 公開日: 2018-05-09, 最終更新日: 2024-03-06)

• 主引用文献: Iwai, K.,Yaguchi, M.,Klein, M.G.; A novel CLK inhibitor exhibits anti-tumor efficacies via modulating pre-mRNA splicing and targeting a MYC-dependent vulnerability; Embo Mol Med, 2018

実験手法

X-RAY DIFFRACTION (2.92 Å)