5UMO

STRUCTURE OF EXTRACELLULAR SIGNAL-REGULATED KINASE

「1ERK」から置き換えられました

5UMO の概要

• エントリーDOI: 10.2210/pdb5umo/pdb
• 分子名称: Mitogen-activated protein kinase 1, SULFATE ION (3 entities in total)
• 機能のキーワード: kinase, erk2, transferase
• 由来する生物種: Rattus norvegicus (Rat)
• 細胞内の位置: Cytoplasm, cytoskeleton, spindle : P63086
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42255.50

構造登録者

CHLEBOWICZ, J.,ZHANG, F.,GOLDSMITH, E.J. (登録日: 2017-01-27, 公開日: 2017-03-01, 最終更新日: 2024-05-22)

主引用文献

Zhang, F.,Strand, A.,Robbins, D.,Cobb, M.H.,Goldsmith, E.J.
Atomic structure of the MAP kinase ERK2 at 2.3 A resolution.
Nature, 367:704-711, 1994

PubMed Abstract: The structure of the MAP kinase ERK2, a ubiquitous protein kinase target for regulation by Ras and Raf, has been solved in its unphosphorylated low-activity conformation to a resolution of 2.3 A. The two domains of unphosphorylated ERK2 are farther apart than in the active conformation of cAMP-dependent protein kinase and the peptide-binding site is blocked by tyrosine 185, one of the two residues that are phosphorylated in the active enzyme. Activation of ERK2 is thus likely to involve both global and local conformational changes.

PubMed: 8107865
DOI: 10.2210/pdb1erk/pdb

実験手法

X-RAY DIFFRACTION (2.26 Å)