5UME

Crystal Structure of 5,10-Methylenetetrahydrofolate Reductase MetF from Haemophilus influenzae

5UME の概要

• エントリーDOI: 10.2210/pdb5ume/pdb
• 分子名称: 5,10-methylenetetrahydrofolate reductase, FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION, ... (7 entities in total)
• 機能のキーワード: alpha-beta structure, tim barrel, structural genomics, center for structural genomics of infectious diseases, csgid, oxidoreductase
• 由来する生物種: Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 205782.81

構造登録者

Kim, Y.,Mulligan, R.,Maltseva, N.,Grimshaw, S.,Anderson, W.F.,Joachimiak, A.,Center for Structural Genomics of Infectious Diseases (CSGID) (登録日: 2017-01-27, 公開日: 2017-02-22, 最終更新日: 2025-06-25)

主引用文献

Inniss, N.L.,Minasov, G.,Chang, C.,Tan, K.,Kim, Y.,Maltseva, N.,Stogios, P.,Filippova, E.,Michalska, K.,Osipiuk, J.,Jaroszewki, L.,Godzik, A.,Savchenko, A.,Joachimiak, A.,Anderson, W.F.,Satchell, K.J.F.
Structural genomics of bacterial drug targets: Application of a high-throughput pipeline to solve 58 protein structures from pathogenic and related bacteria.
Microbiol Resour Announc, 14:e0020025-e0020025, 2025

PubMed Abstract: Antibiotic resistance remains a leading cause of severe infections worldwide. Small changes in protein sequence can impact antibiotic efficacy. Here, we report deposition of 58 X-ray crystal structures of bacterial proteins that are known targets for antibiotics, which expands knowledge of structural variation to support future antibiotic discovery or modifications.

PubMed: 40391899
DOI: 10.1128/mra.00200-25

実験手法

X-RAY DIFFRACTION (2.7 Å)