5UKF

Crystal Structure of the Human Vaccinia-related Kinase 1 Bound to an Oxindole Inhibitor

5UKF の概要

• エントリーDOI: 10.2210/pdb5ukf/pdb
• 分子名称: Serine/threonine-protein kinase VRK1, 4-{[(Z)-(7-oxo-6,7-dihydro-8H-[1,3]thiazolo[5,4-e]indol-8-ylidene)methyl]amino}benzene-1-sulfonamide, PHOSPHATE ION, ... (6 entities in total)
• 機能のキーワード: transferase, protein kinase domain, structural genomics, structural genomics consortium, sgc, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 166712.96

構造登録者

Counago, R.M.,Wells, C.,Zuercher, W.,Willson, T.M.,Bountra, C.,Edwards, A.M.,Arruda, P.,Gileadi, O.,Structural Genomics Consortium (SGC) (登録日: 2017-01-22, 公開日: 2017-03-29, 最終更新日: 2023-10-04)

• 主引用文献: Counago, R.M.,Allerston, C.K.,Savitsky, P.,Azevedo, H.,Godoi, P.H.,Wells, C.I.,Mascarello, A.,de Souza Gama, F.H.,Massirer, K.B.,Zuercher, W.J.,Guimaraes, C.R.W.,Gileadi, O.; Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations.; Sci Rep, 7:7501-7501, 2017; PubMed: 28790404; DOI: 10.1038/s41598-017-07755-y

実験手法

X-RAY DIFFRACTION (2.4 Å)