5UJB
Structure of a Mcl-1 Inhibitor Binding to Site 3 of Human Serum Albumin
Summary for 5UJB
Entry DOI | 10.2210/pdb5ujb/pdb |
Descriptor | Serum albumin, 4-{8-chloro-11-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-1-oxo-7-(1,3,5-trimethyl-1H-pyrazol-4-yl)-4,5-dihydro-1H-[1,4]diazepino[1,2-a]indol-2(3H)-yl}-1-methyl-1H-indole-6-carboxylic acid, PHOSPHATE ION (3 entities in total) |
Functional Keywords | human serum albumin, free fraction, apoptosis, cancer, mcl-1, drug discovery, transport protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 140554.66 |
Authors | Zhao, B. (deposition date: 2017-01-17, release date: 2017-05-03, Last modification date: 2023-10-04) |
Primary citation | Zhao, B.,Sensintaffar, J.,Bian, Z.,Belmar, J.,Lee, T.,Olejniczak, E.T.,Fesik, S.W. Structure of a Myeloid cell leukemia-1 (Mcl-1) inhibitor bound to drug site 3 of Human Serum Albumin. Bioorg. Med. Chem., 25:3087-3092, 2017 Cited by PubMed: 28428041DOI: 10.1016/j.bmc.2017.03.060 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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