5UIX
Crystal Structure of the DH576 CD4bs Fab (unliganded) from the RV305 HIV Vaccine Trial
Summary for 5UIX
Entry DOI | 10.2210/pdb5uix/pdb |
EMDB information | 8573 |
Descriptor | DH576 Fab heavy chain, DH576 Fab light chain (3 entities in total) |
Functional Keywords | fab fragment, hiv-1, antibody, immune system |
Biological source | Homo sapiens More |
Total number of polymer chains | 2 |
Total formula weight | 48318.93 |
Authors | Fera, D.,Harrison, S.C. (deposition date: 2017-01-15, release date: 2017-03-08, Last modification date: 2023-10-04) |
Primary citation | Easterhoff, D.,Moody, M.A.,Fera, D.,Cheng, H.,Ackerman, M.,Wiehe, K.,Saunders, K.O.,Pollara, J.,Vandergrift, N.,Parks, R.,Kim, J.,Michael, N.L.,O'Connell, R.J.,Excler, J.L.,Robb, M.L.,Vasan, S.,Rerks-Ngarm, S.,Kaewkungwal, J.,Pitisuttithum, P.,Nitayaphan, S.,Sinangil, F.,Tartaglia, J.,Phogat, S.,Kepler, T.B.,Alam, S.M.,Liao, H.X.,Ferrari, G.,Seaman, M.S.,Montefiori, D.C.,Tomaras, G.D.,Harrison, S.C.,Haynes, B.F. Boosting of HIV envelope CD4 binding site antibodies with long variable heavy third complementarity determining region in the randomized double blind RV305 HIV-1 vaccine trial. PLoS Pathog., 13:e1006182-e1006182, 2017 Cited by PubMed: 28235027DOI: 10.1371/journal.ppat.1006182 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.501 Å) |
Structure validation
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