5UIG
Crystal structure of adenosine A2A receptor bound to a novel triazole-carboximidamide antagonist
Summary for 5UIG
Entry DOI | 10.2210/pdb5uig/pdb |
Descriptor | Adenosine receptor A2a,Soluble cytochrome b562,Adenosine receptor A2a, {[-(BIS-CARBOXYMETHYL-AMINO)-ETHYL]-CARBOXYMETHYL-AMINO}-ACETIC ACID, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (4 entities in total) |
Functional Keywords | adenosine, a2a receptor, gpcr, vapor diffusion, allosteric, parkinson's disease, adenosine binding protein |
Biological source | Homo sapiens (Human) More |
Cellular location | Cell membrane; Multi-pass membrane protein: P29274 |
Total number of polymer chains | 1 |
Total formula weight | 50364.75 |
Authors | Sun, B.,Bachhawat, P.,Ling-Hon Chu, M.,Ceska, T.,Sands, Z.,Lebon, F.,Kobilka, T.S.,Kobilka, B. (deposition date: 2017-01-13, release date: 2017-02-08, Last modification date: 2023-10-04) |
Primary citation | Sun, B.,Bachhawat, P.,Chu, M.L.,Wood, M.,Ceska, T.,Sands, Z.A.,Mercier, J.,Lebon, F.,Kobilka, T.S.,Kobilka, B.K. Crystal structure of the adenosine A2A receptor bound to an antagonist reveals a potential allosteric pocket. Proc. Natl. Acad. Sci. U.S.A., 114:2066-2071, 2017 Cited by PubMed: 28167788DOI: 10.1073/pnas.1621423114 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.5 Å) |
Structure validation
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