5UIG

Crystal structure of adenosine A2A receptor bound to a novel triazole-carboximidamide antagonist

5UIG の概要

• エントリーDOI: 10.2210/pdb5uig/pdb
• 分子名称: Adenosine receptor A2a,Soluble cytochrome b562,Adenosine receptor A2a, {[-(BIS-CARBOXYMETHYL-AMINO)-ETHYL]-CARBOXYMETHYL-AMINO}-ACETIC ACID, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (4 entities in total)
• 機能のキーワード: adenosine, a2a receptor, gpcr, vapor diffusion, allosteric, parkinson's disease, adenosine binding protein
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Cell membrane; Multi-pass membrane protein: P29274
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 50364.75

構造登録者

Sun, B.,Bachhawat, P.,Ling-Hon Chu, M.,Ceska, T.,Sands, Z.,Lebon, F.,Kobilka, T.S.,Kobilka, B. (登録日: 2017-01-13, 公開日: 2017-02-08, 最終更新日: 2023-10-04)

• 主引用文献: Sun, B.,Bachhawat, P.,Chu, M.L.,Wood, M.,Ceska, T.,Sands, Z.A.,Mercier, J.,Lebon, F.,Kobilka, T.S.,Kobilka, B.K.; Crystal structure of the adenosine A2A receptor bound to an antagonist reveals a potential allosteric pocket.; Proc. Natl. Acad. Sci. U.S.A., 114:2066-2071, 2017; PubMed: 28167788; DOI: 10.1073/pnas.1621423114

実験手法

X-RAY DIFFRACTION (3.5 Å)