5UFW
Estrogen Receptor Alpha Ligand Binding Domain in Complex with OP1154
Summary for 5UFW
Entry DOI | 10.2210/pdb5ufw/pdb |
Descriptor | Estrogen receptor, (2S)-3-(4-hydroxyphenyl)-4-methyl-2-(4-{2-[(3S)-3-methylpyrrolidin-1-yl]ethoxy}phenyl)-2H-1-benzopyran-7-ol (3 entities in total) |
Functional Keywords | estrogen, breast cancer, hormone, nuclear hormone receptor, transcription |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 57625.54 |
Authors | Fanning, S.W.,Hodges-Gallagher, L.,Myles, D.C.,Sun, R.,Fowler, C.E.,Green, B.D.,Harmon, C.L.,Greene, G.L.,Kushner, P.J. (deposition date: 2017-01-06, release date: 2018-01-10, Last modification date: 2023-10-04) |
Primary citation | Fanning, S.W.,Hodges-Gallagher, L.,Myles, D.C.,Sun, R.,Fowler, C.E.,Plant, I.N.,Green, B.D.,Harmon, C.L.,Greene, G.L.,Kushner, P.J. Specific stereochemistry of OP-1074 disrupts estrogen receptor alpha helix 12 and confers pure antiestrogenic activity. Nat Commun, 9:2368-2368, 2018 Cited by PubMed: 29915250DOI: 10.1038/s41467-018-04413-3 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.583 Å) |
Structure validation
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