5UFP

Crystal structure of PT2399 bound to HIF2a-B*:ARNT-B* complex

Replaces:  5T0T

Summary for 5UFP

• Entry DOI: 10.2210/pdb5ufp/pdb
• Descriptor: Endothelial PAS domain-containing protein 1, Aryl hydrocarbon receptor nuclear translocator, 3-({(1S)-7-[(difluoromethyl)sulfonyl]-2,2-difluoro-1-hydroxy-2,3-dihydro-1H-inden-4-yl}oxy)-5-fluorobenzonitrile, ... (4 entities in total)
• Functional Keywords: hif2 inhibitor hif2 ligand pas-b hypoxia inducible factor 2 epas1, transcription
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus : Q99814 P27540
• Total number of polymer chains: 2
• Total formula weight: 27467.92

Authors

Du, X. (deposition date: 2017-01-05, release date: 2017-01-25, Last modification date: 2024-03-06)

• Primary citation: Cho, H.,Du, X.,Rizzi, J.P.,Liberzon, E.,Chakraborty, A.A.,Gao, W.,Carvo, I.,Signoretti, S.,Bruick, R.K.,Josey, J.A.,Wallace, E.M.,Kaelin, W.G.; On-target efficacy of a HIF-2 alpha antagonist in preclinical kidney cancer models.; Nature, 539:107-111, 2016; PubMed: 27595393; DOI: 10.1038/nature19795

Experimental method

X-RAY DIFFRACTION (1.9 Å)