5UF0
BRD4_BD2-A-35165
Summary for 5UF0
Entry DOI | 10.2210/pdb5uf0/pdb |
Related | 5UEO 5UEP 5UEQ 5UER 5UES 5UET 5UEU 5UEV 5UEW 5UEX 5UEY 5UEZ |
Descriptor | Bromodomain-containing protein 4, 2-methyl-5-(methylamino)-6-phenylpyridazin-3(2H)-one (3 entities in total) |
Functional Keywords | helix bundle, signaling protein-inhibitor complex, signaling protein/inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus: O60885 |
Total number of polymer chains | 1 |
Total formula weight | 13022.18 |
Authors | Park, C.H. (deposition date: 2017-01-03, release date: 2017-06-28, Last modification date: 2024-04-03) |
Primary citation | Wang, L.,Pratt, J.K.,Soltwedel, T.,Sheppard, G.S.,Fidanze, S.D.,Liu, D.,Hasvold, L.A.,Mantei, R.A.,Holms, J.H.,McClellan, W.J.,Wendt, M.D.,Wada, C.,Frey, R.,Hansen, T.M.,Hubbard, R.,Park, C.H.,Li, L.,Magoc, T.J.,Albert, D.H.,Lin, X.,Warder, S.E.,Kovar, P.,Huang, X.,Wilcox, D.,Wang, R.,Rajaraman, G.,Petros, A.M.,Hutchins, C.W.,Panchal, S.C.,Sun, C.,Elmore, S.W.,Shen, Y.,Kati, W.M.,McDaniel, K.F. Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors. J. Med. Chem., 60:3828-3850, 2017 Cited by PubMed: 28368119DOI: 10.1021/acs.jmedchem.7b00017 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.35 Å) |
Structure validation
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