5UEZ

BRD4_BD2_A-1342843

Summary for 5UEZ

• Entry DOI: 10.2210/pdb5uez/pdb
• Related: 5UEO 5UEP 5UEQ 5UER 5UES 5UET 5UEU 5UEV 5UEW 5UEX 5UEY 5UF0
• Descriptor: Bromodomain-containing protein 4, 5-methoxy-2-methyl-6-(2-phenoxyphenyl)pyridazin-3(2H)-one (3 entities in total)
• Functional Keywords: signaling protein-inhibitor complex, signaling protein/inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus: O60885
• Total number of polymer chains: 1
• Total formula weight: 13115.26

Authors

Park, C.H. (deposition date: 2017-01-03, release date: 2017-05-10, Last modification date: 2024-04-03)

• Primary citation: Wang, L.,Pratt, J.K.,Soltwedel, T.,Sheppard, G.S.,Fidanze, S.D.,Liu, D.,Hasvold, L.A.,Mantei, R.A.,Holms, J.H.,McClellan, W.J.,Wendt, M.D.,Wada, C.,Frey, R.,Hansen, T.M.,Hubbard, R.,Park, C.H.,Li, L.,Magoc, T.J.,Albert, D.H.,Lin, X.,Warder, S.E.,Kovar, P.,Huang, X.,Wilcox, D.,Wang, R.,Rajaraman, G.,Petros, A.M.,Hutchins, C.W.,Panchal, S.C.,Sun, C.,Elmore, S.W.,Shen, Y.,Kati, W.M.,McDaniel, K.F.; Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors.; J. Med. Chem., 60:3828-3850, 2017; PubMed: 28368119; DOI: 10.1021/acs.jmedchem.7b00017

Experimental method

X-RAY DIFFRACTION (1.51 Å)